berberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat
نویسندگان
چکیده
parkinson’s disease (pd) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. current treatments for pd afford symptomatic relief with no prevention of disease progression. due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (bbr), this study was conducted to assess whether bbr pretreatment could attenuate behavioral and neuronal derangement in 6-hydroxydopamine (6-ohda)-induced model of pd in the rat. unilateral intrastriatal 6-ohda-lesioned rats received bbr at doses of 25 and/or 50 mg/kg (i.p.) three times at an interval of 24 h, started 2 days before the surgery. after 1 week, apomorphine caused significant contralateral rotations and a significant reduction in the number of nissl-stained and tyrosine-hydroxylase (th)-positive neurons on the left side of the substantianigra. bbr pretreatment at a dose of 50 mg/kg significantly reduced rotations and prevented loss of th-positive neurons. these results indicate pre-lesion administration of bbr could protect against 6-ohda toxicity and this may be of benefit besides other available therapies in pd.
منابع مشابه
Berberine Chloride Pretreatment Exhibits Neuroprotective Effect Against 6-Hydroxydopamine-Induced Neuronal Insult in Rat
Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...
متن کاملBerberine Chloride Pretreatment Exhibits Neuroprotective Effect Against 6-Hydroxydopamine-Induced Neuronal Insult in Rat
Parkinson’s disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...
متن کاملBerberine chloride pretreatment exhibits neuroprotective effect against 6-hydroxydopamine-induced neuronal insult in rat
Parkinson's disease (PD) is a rather common movement disorder as a result of the degeneration of dopaminergic neurons within the substantianigra. Current treatments for PD afford symptomatic relief with no prevention of disease progression. Due to the neuroprotective and anti-apoptotic potential of the isoquinoline alkaloid berberine (BBR), this study was conducted to assess whether BBR pretrea...
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متن کاملNeuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
متن کاملNeuroprotective Effect of Thymoquinone, the Nigella Sativa Bioactive Compound, in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rat Model
Parkinson disease (PD) is the most common movement disorder with progressive degeneration of midbrain dopaminergic neurons for which current treatments afford symptomatic relief with no-prevention of disease progression. Due to the neuroprotective property of the Nigella sativa bioactive compound thymoquinone (TQ), this study was undertaken to evaluate whether TQ could improve behavioral and ce...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۴، شماره ۴، صفحات ۱۱۴۵-۱۱۵۲
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